Jennifer Connelly voices the Spider-Man computer Karen. Her husband Paul Bettany had voiced the Iron Man computer J.A.R.V.I.S. She was also cast, because of her appearance in the John Hughes produced Career Opportunities (1991). "Homecoming" pays homage to Hughes' high school films, and casting Connelly was done as a tribute to his career. Connelly was also previously cast as Elizabeth "Betty" Ross in Hulk (2003).